Repligen XCell Lab System

The Repligen XCell Lab System is a specialized crossflow filtration (TFF) platform designed for laboratory-scale process development. The system is primarily used for the concentration and diafiltration of biomolecules such as proteins, antibodies, and viral vectors.

Key Features
Pro-Connex Flow Pad: Utilizes a unique, disposable flow pad design that minimizes the need for cleaning (CIP) and prevents cross-contamination.
Automation: The system provides automated control over process parameters such as transmembrane pressure (TMP), flow rates, and filtration volumes.
Scalability: Results obtained on the Lab System are directly scalable to larger XCell Pilot and Process systems.
Filter Compatibility: Optimized for use with Repligen TangenX SIUS cassettes (disposable) and reusable cassettes.

Technical Specifications
Flow Range: Suitable for volumes from approximately 50 ml to 10 liters.
Sensors: Integrated pressure sensors and scale connections allow for accurate monitoring of filtration rate and yield.
Software: Uses an intuitive interface that enables real-time data logging and graphical process visualization.

User Benefits
According to reviews in the biopharmaceutical industry (such as on Biocompare), the system is praised for:
Speed: The ability to optimize processes in hours instead of days.
Consistency: High reproducibility between batches.
Flexibility: Easily switch between different membrane types and pore sizes.
Footprint: The ATF 1 and 2 units have a very small footprint of approximately 0.04 m², while the ATF 4 takes up approximately 0.13 m².
Housing: The filter housings vary in height from approximately 36 cm to 61 cm, depending on the scale of the process.
Controller Space: For the XCell C24 Controller (often used in lab setups), a recommended workspace of approximately 36 x 37 x 25 cm (H x W x D) is recommended to properly accommodate all connections and fittings.

A complete setup including controller, pump, and ATF device typically requires a standard laboratory bench surface approximately 1 meter wide. The total system weight (excluding fluid) is typically between 20 and 30 kg.